USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database 
Search by   *

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
Searching in 'USC-OGP 2-DE database' for entry matching: Q9UL46

USC-OGP 2-DE database:  Q9UL46


General information about the entry
View entry in simple text format
Entry namePSME2_HUMAN
Primary accession numberQ9UL46
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Proteasome activator complex subunit 2; AltName: Full=11S regulator complex subunit beta; Short=REG-beta; AltName: Full=Activator of multicatalytic protease subunit 2; AltName: Full=Proteasome activator 28 subunit beta; Short=PA28b; Short=PA28beta;.
Gene nameName=PSME2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

Homo sapiens (Human)
  map experimental info

pI=5.27; Mw=30221

Homo sapiens (Human)
  map experimental info

pI=5.24; Mw=30825

Homo sapiens (Human)
  map experimental info

pI=5.39; Mw=30456

UniProtKB/Swiss-ProtQ9UL46; PSME2_HUMAN.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry namePSME2_HUMAN
Primary accession numberQ9UL46
Secondary accession number(s) Q15129
Sequence was last modified on May 18, 2010 (version 4)
Annotations were last modified on March 15, 2017 (version 159)
Name and origin of the protein
DescriptionRecName: Full=Proteasome activator complex subunit 2; AltName: Full=11S regulator complex subunit beta; Short=REG-beta; AltName: Full=Activator of multicatalytic protease subunit 2; AltName: Full=Proteasome activator 28 subunit beta; Short=PA28b; Short=PA28beta;
Gene nameName=PSME2
Encoded onName=PSME2
KeywordsAcetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Proteasome; Reference proteome.
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
EMBLAF079558; AAF02218.1; -; Genomic_DNA
EMBLD45248; BAA08205.1; -; mRNA
EMBLBC004368; AAH04368.1; -; mRNA
EMBLBC019885; AAH19885.1; -; mRNA
EMBLBC072025; AAH72025.1; -; mRNA
CCDSCCDS9614.1; -; .
PIRI53518; I53518; .
RefSeqNP_002809.2; NM_002818.2; .
UniGeneHs.434081; -; .
UniGeneHs.512410; -; .
ProteinModelPortalQ9UL46; -; .
SMRQ9UL46; -; .
BioGrid111693; 56; .
IntActQ9UL46; 23; .
MINTMINT-1478095; -; .
STRING9606.ENSP00000216802; -; .
iPTMnetQ9UL46; -; .
PhosphoSitePlusQ9UL46; -; .
SwissPalmQ9UL46; -; .
BioMutaPSME2; -; .
DMDM296453017; -; .
OGPQ9UL46; -; .
EPDQ9UL46; -; .
MaxQBQ9UL46; -; .
PaxDbQ9UL46; -; .
PeptideAtlasQ9UL46; -; .
PRIDEQ9UL46; -; .
TopDownProteomicsQ9UL46; -; .
DNASU5721; -; .
EnsemblENST00000216802; ENSP00000216802; ENSG00000100911; .
GeneID5721; -; .
KEGGhsa:5721; -; .
UCSCuc001wmj.4; human; .
CTD5721; -; .
DisGeNET5721; -; .
GeneCardsMIR7703; -; .
GeneCardsPSME2; -; .
HPAHPA062661; -; .
MIM602161; gene; .
neXtProtNX_Q9UL46; -; .
OpenTargetsENSG00000100911; -; .
PharmGKBPA33915; -; .
eggNOGKOG4470; Eukaryota; .
GeneTreeENSGT00510000046374; -; .
HOGENOMHOG000282822; -; .
HOVERGENHBG053745; -; .
InParanoidQ9UL46; -; .
KOK06697; -; .
PhylomeDBQ9UL46; -; .
TreeFamTF106236; -; .
ReactomeR-HSA-1169091; Activation of NF-kappaB in B cells; .
ReactomeR-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; .
ReactomeR-HSA-1236974; ER-Phagosome pathway; .
ReactomeR-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); .
ReactomeR-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; .
ReactomeR-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; .
ReactomeR-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; .
ReactomeR-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; .
ReactomeR-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; .
ReactomeR-HSA-180534; Vpu mediated degradation of CD4; .
ReactomeR-HSA-180585; Vif-mediated degradation of APOBEC3G; .
ReactomeR-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; .
ReactomeR-HSA-195253; Degradation of beta-catenin by the destruction complex; .
ReactomeR-HSA-202424; Downstream TCR signaling; .
ReactomeR-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; .
ReactomeR-HSA-2467813; Separation of Sister Chromatids; .
ReactomeR-HSA-2871837; FCERI mediated NF-kB activation; .
ReactomeR-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; .
ReactomeR-HSA-350562; Regulation of ornithine decarboxylase (ODC); .
ReactomeR-HSA-382556; ABC-family proteins mediated transport; .
ReactomeR-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; .
ReactomeR-HSA-4608870; Asymmetric localization of PCP proteins; .
ReactomeR-HSA-4641257; Degradation of AXIN; .
ReactomeR-HSA-4641258; Degradation of DVL; .
ReactomeR-HSA-5358346; Hedgehog ligand biogenesis; .
ReactomeR-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; .
ReactomeR-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; .
ReactomeR-HSA-5607764; CLEC7A (Dectin-1) signaling; .
ReactomeR-HSA-5610780; Degradation of GLI1 by the proteasome; .
ReactomeR-HSA-5610783; Degradation of GLI2 by the proteasome; .
ReactomeR-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; .
ReactomeR-HSA-5632684; Hedgehog 'on' state; .
ReactomeR-HSA-5658442; Regulation of RAS by GAPs; .
ReactomeR-HSA-5668541; TNFR2 non-canonical NF-kB pathway; .
ReactomeR-HSA-5676590; NIK-->noncanonical NF-kB signaling; .
ReactomeR-HSA-5678895; Defective CFTR causes cystic fibrosis; .
ReactomeR-HSA-5687128; MAPK6/MAPK4 signaling; .
ReactomeR-HSA-5689603; UCH proteinases; .
ReactomeR-HSA-5689880; Ub-specific processing proteases; .
ReactomeR-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; .
ReactomeR-HSA-68949; Orc1 removal from chromatin; .
ReactomeR-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; .
ReactomeR-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; .
ReactomeR-HSA-69481; G2/M Checkpoints; .
ReactomeR-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; .
ReactomeR-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; .
ReactomeR-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; .
ReactomeR-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; .
ChiTaRSPSME2; human; .
GeneWikiPSME2; -; .
GenomeRNAi5721; -; .
PROPR:Q9UL46; -; .
ProteomesUP000005640; Chromosome 14; .
BgeeENSG00000100911; -; .
CleanExHS_PSME2; -; .
ExpressionAtlasQ9UL46; baseline and differential; .
GenevisibleQ9UL46; HS; .
GOGO:0005737; C:cytoplasm; IBA:GO_Central; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0016020; C:membrane; IDA:UniProtKB; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0008537; C:proteasome activator complex; IEA:InterPro; .
GOGO:0000502; C:proteasome complex; TAS:ProtInc; .
GOGO:0061133; F:endopeptidase activator activity; IBA:GO_Central; .
GOGO:0042802; F:identical protein binding; IPI:IntAct; .
GOGO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; .
GOGO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome
GOGO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; .
GOGO:0000165; P:MAPK cascade; TAS:Reactome; .
GOGO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; .
GOGO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; .
GOGO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; .
GOGO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; .
GOGO:0010950; P:positive regulation of endopeptidase activity; IBA:GO_Central; .
GOGO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; .
GOGO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; .
GOGO:0016579; P:protein deubiquitination; TAS:Reactome; .
GOGO:0000209; P:protein polyubiquitination; TAS:Reactome; .
GOGO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; .
GOGO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central; .
GOGO:0043488; P:regulation of mRNA stability; TAS:Reactome; .
GOGO:0061136; P:regulation of proteasomal protein catabolic process; IBA:GO_Central; .
GOGO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; .
GOGO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; .
GOGO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; .
GOGO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; .
GOGO:0055085; P:transmembrane transport; TAS:Reactome; .
GOGO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; .
GOGO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome
Gene3D1.20.120.180; -; 1; .
Gene3D1.20.5.120; -; 1; .
InterProIPR009077; Proteasome_activ_pa28; .
InterProIPR003186; Proteasome_activ_pa28_C; .
InterProIPR003185; Proteasome_activ_pa28_N; .
PANTHERPTHR10660; PTHR10660; 1; .
PfamPF02251; PA28_alpha; 1; .
PfamPF02252; PA28_beta; 1; .
SUPFAMSSF47216; SSF47216; 1; .

USC-OGP 2-DE database image

Gateways to other related servers

Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server